What would cause an inconclusive paternity test result?

Amber Shaw, of IDENTIGENE’s customer service answer’s this weeks Ask Kate question.

Inconclusive paternity test results generated by most laboratories typically means that the probability of paternity was < 99%. This is most likely caused by a number of differences between child and the alleged father at one or more genetic markers (loci) or the alleles (genetic variations) shared between child and the alleged father were so common that the collective strength of all the markers did not add enough statistical strength to the calculation to give a definitive “not excluded” result.

Differences between child and the alleged father could be caused by true generational mutations which occur naturally and randomly thru generations. Because the mutations are taken into consideration in the paternity calculations, the probability suffers because the dissimilarities between child and alleged father must be accounted for.

The results calculation is based upon the individual relationship indices (RI). The RI indicates how common, or how rare, each marker is at each locus according to population. If you have one (or more) rare markers that are passed to the child, that index number will increase the combined paternity index (CPI). An inclusive result is a combined parentage index of 99% or higher.

IDENTIGENE releases definitive results based upon two things:

  1. Inclusions: Probability of paternity of 99% or higher.
  2. Exclusions: 3 or more exclusionary markers (alleles do not match between child and the alleged father).

Many laboratories release an exclusion result requiring only 2 exclusionary markers be present. Our minimum is a more conservative number of 3 exclusionary markers. Although it is less likely to have 2 differences between a child and true biological father, it is still possible and based upon what is seen in the laboratory, implies there needs to be more investigation because a close relative of the alleged father (such as the father or brother of the alleged father)  could potentially be the father . IDENTIGENE releases a result of inconclusive when there are 2 differences between child and an alleged father for two reasons:

  1. Because exclusionary results are definitive, we take a more cautious and conservative approach to ensure the result is as accurate as possible.
  2. Typically when two differences exist between child and the alleged father, the brother of the alleged father is a potential candidate for being the true biological father. This is based upon experience on what is actually seen in the laboratory and deserves closer examination.

Read here for more information on understanding the Paternity Index: http://www.dnatesting.com/dna-testing/paternity-index.php

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Twitter Weekly Updates for 2010-07-11

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Twitter Weekly Updates for 2010-07-04

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Identigene on Thalia Radio

The Identigene DNA paternity test kit was featured Father’s Day weekend on Conexion Thalia, a popular Spanish-language radio program syndicated in more than 40 U.S. markets. The show featured an Identigene customer, Lazaro, and Edgar Gomez, a representative from Identigene.

The show’s home page is: http://thaliaradio.com/es/.

The following update is by Identigene Spanish Language Test Consultant Karen J.

Identigene on Thalia Radio

Thalía in her High Voltage Tour Los Angeles concert (Los Angeles, CA, USA, May 14, 2004).

First, a little background about Thalía; Thalía is a Mexican singer and former actress. She is known globally as “the queen of soaps” for being the biggest TV phenomenon in the decade of 90s. Thalía has the keys of more than 50 cities in the world, and has toured in five continents, making her one of the most internationally famous Latin singers ever. Thalía has received more than 2000 awards throughout her career for both singing and acting and is a multi-platinum singer. Thalía sold over 40 million records, with a career based on Hispanic language and reaching a high mark for a Latin artist.

Introduction

The show begins with host Thalía giving a brief explanation of the scientific advances in paternity testing and how Identigene’s paternity tests can provide peace of mind and show the biological link between fathers and children or any other relatives.

Interviews

Thalía begins by interviewing Edgar Gomez, an Identigene representative. She asks basic questions about the Identigene paternity test kit, the test, the samples collection and also Immigration cases. She was impressed by how accurate paternity testing can be, as we as how fast and easy the process is.

Introducing Lazaro’s story

Thalía and Edgar present the story of Lazaro. A man who’s life totally changed thanks to the Identigne paternity test. Lazaro came out of Cuba 17 years ago, and while in Cuba had a relationship with a young Cuban lady. Lazaro had been in the United States for two years when his mother told him that this woman had a baby and the baby was his. Lazaro was skeptical, but he had been diagnosed with prostate cancer and undergone a prostate removal. The birth of this baby presented the opportunity for him to become a real father.

Lazaro described the moment when he received the report with a probability of paternity of 99.9% and his call to Cecilia, his daughter in Cuba, to give her the good news.

After congratulating Lazaro, Thalía shares the mission of her radio program, the focus on constructive stories of love and peace. Pausing, she introduces Lazaro’s daughter, Cecilia, on the other line from Cuba.

Cecilia is a little nervous to be on the radio with Thalía, but she is very happy. Cecilia and Lazaro say many times how much they love each other.
Thalía shares her excitement at being part of such a touching moment. Thanking them both, she asks Lazaro to encourage other fathers who still don’t know. Lazaro says: “I would like to say; allow yourself to be a father. Try it, don’t hesitate.”

Ending the program

Thalía ends the program by thanking Edgar, Lazaro, and Cecilia for sharing their story and asks to all fathers who are waiting to know if they are parents to remember Lazaro’s experience.

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Posted in DNA Relationship Testing, DNA Testing for Immigration, Gossip & Opinion, Paternity Testing.


Twitter Weekly Updates for 2010-06-27

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I’m my own Grandpa?

If you are part of a large family, like I am, you are bound to have those relatives… the ones that you KNOW you are related to, but you never know quite sure what to call them.

“Yah, she’s my niece’s  cousin’s son.”

Or maybe you are just wonder what the difference is between “second cousins” or what does “once removed” mean?

Wolfram|Alpha can help you figure out the relationship between your relatives.
http://blog.wolframalpha.com/2010/06/21/my-cousins-cousins-nieces-grandfather-said-to-just-ask-wolframalpha/

Just type in the relationship you want to figure out, and you’ll be presented with a family tree and possible names for the relationship. More information is available too, like the number of generations different, the blood relationship faction or the probability for shared x or y chromosomes.

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Posted in Ancestry.


Thackary’s Time: A documentary on paternity, fatherhood, and identity

Thackary’s Time, a 54-minute documentary by Kathy Klausner and Beni Strebel

“How important is it to know your biological father? And what happens when you discover that he isn’t who you thought he was for the first 39 years of your life? Those are the questions at the heart of Thackary’s Time, a 54-minute documentary by Kathy Klausner and Beni Strebel.”

From the website:

Thackary is a footloose, free-spirited Northern Californian, who finds love time and time again. His life takes a dramatic turn when his mother tells him that the man who raised him is not his biological father. Thackary Grossman, a 39-year-old occasional carpenter and surfer, sets out to discover a new father and define his own identity.

I just came accross this documentary, I think it raises some interesting points about family, fatherhood, and identity. In a time when most people know about paternity tests from the “Maury Show” and such, I think it can be easy to lose sight of the deep impact that paternity has on everyones lives; the biological father, the mother and the child. I’m excited to see this important subject presented in the media in such an introspective and caring way.

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Posted in Gossip & Opinion, Paternity Testing.


Twitter Weekly Updates for 2010-05-30

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What is the best solution?

From a product question on Walmart.com:

Q: If the child lives way across the country from the potential father, what is the best solution to get the dna sampling done? I would love to use this product and service but would like to know a suggestion or solution to this.

A: The swabs and envelopes are safe to ship by mail, so you can purchase a paternity test kit and then send a swab packet and collection envelope across the country to the child. They can collect and send their sample directly to Identigene or return it to you and you can send in all samples at once.

If the child is old enough, they could purchase a second DNA paternity kit and send a sample directly to the lab. You would still only pay one paternity test lab fee, but you’d pay for two kits. This might be a bit more expensive, but may also be faster than waiting for the mail.

In either case, you should call Identigene and pay for the paternity test fee by phone before sending in samples (1-888-404-4363). You will then get a case number that can be written on each envelope (or order form) so the lab can easily match them up when they arrive.

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Can a paternity test be performed on just one alleged father?

Q: I have multiple possible fathers but only one has agreed to the dna test. Can I do a paternity test with just one possible father?

A: Yes, we can do paternity testing with just one alleged father and the child. The results of the paternity test will tell you if he is the father or not. If he is not the father, you would then the other possible fathers to participate in a paternity test.

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